Some hallucinogens are natural plants or mushrooms and some are man-made. How you will feel on these drugs is unpredictable. You might feel extremely happy, relaxed, spiritually inspired or open to the world in a new way. Or you might feel scared, lonely, sad or overwhelmed.
These effects wear off slowly over 9-12 hours and your sense of reality returns to normal. But the effects of the drug do not always go away once it wears off - it's possible to have mood swings, strong anxiety, and even flashbacks at a later time.
There are two kinds of Hallucinogens: classic hallucinogens (such as LSD) and dissociative drugs (such as PCP). Both types can cause hallucinations. Dissociative drugs can also make you feel out of control or disconnected from your body and surroundings.
Classic hallucinogens
These have been used for centuries as a spiritual and healing tool. But they can also cause intense and rapid emotional changes as well as feelings of panic, fear and loss of control. Classic hallucinogens include:
- LSD, a powerful mind-altering chemical
- Psilocybin, a type of mushroom found in South America, Mexico, and the U.S.
- Peyote (mescaline), a component of a small cactus. It can also be man-made.
- DMT, a powerful chemical found in some Amazonian plants. Ayahuasca is a tea made from those plants. DMT is also made in a lab as a white powder that is smoked
- 251-NBOMe, a man-made hallucinogen similar to LSD and MDMA (Ecstasy) but much stronger
Dissociative Drugs
These are most often used socially - to have fun, as club drugs, to deal with stress, and in the most negative way as “date rape drugs.” They include:
- PCP, found as tablets, capsules, liquid and white crystal powder (the most common)
- Ketamine, an anesthetic used for surgery, sold as a powder, pill, or injectable liquid. It can be snorted or added to drinks as a date-rape drug
- Dextromethorphan (DXM), a cough suppressant found in some over-the-counter cold and cough medicines (syrups, tablets, and gel capsules)
- Salvia, a plant from Mexico and South America. The fresh leaves are chewed or you can drink the extracted juices. The dried leaves are smoked.
IMMEDIATE EFFECTS OF CLASSIC HALLUCINOGENS
Hallucinogens change the way you experience the world. You may have hallucinations, causing you to see, feel, hear and sense things that don’t exist in normal reality. They can also cause strong emotions, quick changes in your mood and the sense that time is slowing down. Some people feel a sense of panic while others may feel deeply relaxed.
They may also cause physical changes such as increased blood pressure and breathing rate, uncoordinated movement and nausea. These effects usually start soon after taking the drug and can last up to 12 hours.
LONG TERM EFFECTS OF CLASSIC HALLUCINOGENS
It is possible to become psychologically addicted to hallucinogens but not physically addicted. Your mind can create a strong desire for it. You can also develop a high degree of tolerance, so you need larger doses to get similar effects. The good news is that tolerance for classic hallucinogens is short-lived, and there are usually no physical withdrawal symptoms when you stop long-term use.
There are two possible but rare long-term effects: flashbacks and persistent psychosis. There is no way to know when or if they will happen and the exact causes are not known. They can happen to anyone, even after a single dose. There is no set treatment for flashbacks. Some antidepressant and antipsychotic drugs may help improve mood and treat psychosis if needed.
IMMEDIATE EFFECTS OF DISSOCIATIVE DRUGS
Dissociative drugs distort what you see and hear and create a sense of floating and separation from reality. You may feel anxious and confused and have memory loss, numbness, and increased blood pressure and heart rate. These effects depend on the amount taken. They can begin within minutes of taking the drug and last for several hours, or even days.
Different dissociative drugs can also produce some dangerous effects.
- At moderate to high doses, PCP can cause seizures, severe muscle contractions, violent behavior, and even psychotic symptoms similar to schizophrenia.
- At moderate to high doses, ketamine can lead to extreme sleepiness, hallucinations, being unable to move your body, and amnesia. At high doses, you might also have frightening feelings of being detached from your senses, likened to a near-death or out-of-body experience called “K-hole”.
- Salvia can cause strong but short-lived effects (up to 30 minutes), including changes of mood ranging from sadness to uncontrollable laughter.
- DXM is safe in a cough medicine when used at recommended doses (typically 15–30 milligrams). But it can lead to serious side effects when abused. Like PCP and ketamine, DXM at doses from 200 to 1,500 milligrams can make you feel removed from your body and your surroundings and almost in a trance-like state. It also increases the risk of seizures, rapid heart rate and trouble breathing.
LONG TERM EFFECTS OF DISSOCIATIVE DRUGS
Dissociative drugs can cause changes in how the heart beats, either too fast, too slow or irregularly. They can also slow down your breathing which raises the level of carbon dioxide in the body, a very dangerous situation.
Repeated use of PCP can lead to tolerance (you need higher doses to get the same effect) and withdrawal symptoms when the drug is stopped. Other effects include memory loss, depression, suicidal thoughts, anxiety, and feeling isolated and lonely -which can last a year or more after chronic use stops.
HOW DO THEY WORK?
Not everything is understood about how hallucinogens work. Researchers think they change the way important natural chemicals in the brain and spinal cord communicate - and this effects your emotions, memory, senses, sleep, hunger, sexual behavior, and muscle control. For example,
- Hallucinogens change how serotonin works – and this effects memory, learning, mood, sleep and heart rate
- PCP, ketamine, and DXM change how glutamate works – and this effects anxiety, depression and the experience of pain
- PCP also changes the action of dopamine - which may be part of how it produces hallucinations and delusions
Below are two reports from NIDA to learn more about how hallucinogens work:
- Research Report Series on Hallucinogens and Dissociative Drugs – a report for the general public.
- Mind Over MatterThe Brain’s Response to Hallucinogens